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Results for "
fosmanogepix
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- FosmanogepixE1211, APX001T113142091769-17-2Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
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SizeQTY - Fosmanogepix TFAT218175Fosmanogepix TFA (APX001 TFA) is an orally active prodrug of APX001A and acts as an antifungal agent. It is effective against Cryptococcus neoformans and Candida auris resistant to Fluconazole. Additionally, Fosmanogepix TFA significantly improves invasive pulmonary aspergillosis and murine pulmonary mucormycosis.
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