fllrn

FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.

YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway. At low concentrations, YFLLRNP (60 μM) does not activate Gq or Gi pathways.

TFLLRN-NH2 is a biologically active peptide functioning as a PAR-1 agonist.

TFLLRNPNDK-NH2 is a biologically active peptide and a thrombin receptor activating peptide (TRAP). As a PAR-1 agonist, it reversibly binds to PAR-1, mimicking the 'tethered ligand' created by thrombin through proteolytic substrate cleavage. It also induces increased liquid and protein permeability, similar to thrombin's effect.

TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 μM).

iso-TRAP-6 (iso-SFLLRN), a hexapeptide derived from the substitution of isoserine for serine, is a protease-activated receptor 1 (PAR1) agonist that activates platelets via PAR-1. iso-TRAP-6 is more resistant to degradation by plasma aminopeptidases than iso-TRAP-6.

TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM [EC50: 1.9 μM (PAR1)].