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By Target- PAD
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Results for "
famidine
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Peptide Products1
F-Amidine TFA
T84479877617-46-4
F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.
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TDFA
Thr-Asp-F-amidine
TP37141345019-64-8
TDFA is an irreversible inhibitor of protein arginine deiminase 4 (PAD4).
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