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  • Sirtuin
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ex527

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  • Inhibitors & Agonists
    3
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Selisistat
SEN0014196, EX-527
T611149843-98-3
Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50 = 38 nM) and can be utilized in the study of neurological disorders such as Huntington's chorea.
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Selisistat R-enantiomer
EX-527 (R-enantiomer)
T15263848193-69-1
Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).
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Selisistat S-enantiomer
EX-527 S-enantiomer, EX-527 (S-enantiomer)
T7058848193-68-0
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2 3.
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