e2/bsa

Estradiol-BSA is a hapten-carrier protein conjugate formed by coupling Estradiol to bovine serum albumin (BSA). As a hapten, Estradiol alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Estradiol-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

NHS-activated 2-octynoic acid-BSA is an immunogen utilized to develop a mouse model for primary biliary cholangitis (PBC). When combined with Complete Freund's Adjuvant, it stimulates the immune system to recognize it as a foreign antigen, triggering an immune response against the body's biliary epithelial cells. This results in the production of anti-PDC-E2 antibodies, causing bile duct damage and inflammation. NHS-activated 2-octynoic acid-BSA is promising for primary biliary cholangitis research.