dspepegamine (mw 3400)

DSPE-PEG-Amine (MW 3400), a polyethylene glycol (PEG)-based PROTAC linker, serves as a crucial component in the synthesis of PROTACs[1].

DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of lipid-based delivery systems. The amine group on DSPE-PEG-Amine, MW 10000 (ammonium) can react with aromatic aldehydes on the surface of bovine carbonic anhydrase (BCA) molecules, forming bisarylhydrazones (BAH) with the target enzyme. This interaction results in a liposome-BAH-BCA conjugate capable of catalyzing the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 1000 (ammonium) is a phosphatidylethanolamine used in the synthesis of lipid-based delivery systems, such as liposomes. The amine group of DSPE-PEG-Amine can be converted into an aromatic aldehyde, which reacts with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. The liposomes form a conjugate with the enzyme molecule through bis-aryl hydrazone (BAH), resulting in a liposome-BAH-BCA conjugate. This conjugate catalyzes the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 5000 (ammonium), is a phosphatidylethanolamine that plays a role in the synthesis of liposomes for delivery systems. The amine group in DSPE-PEG-Amine, MW 5000 (ammonium) can be transformed into an aromatic aldehyde, which reacts with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. The liposomes form bisaryl hydrazone (BAH) conjugates with the target enzyme molecules, resulting in liposome-BAH-BCA conjugates that can catalyze the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker, serving as a crucial component in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].