dspe-peg-amine

DSPE-PEG-Amine (MW 3400), a polyethylene glycol (PEG)-based PROTAC linker, serves as a crucial component in the synthesis of PROTACs[1].

DSPE-PEG-Amine (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker, serving as a crucial component in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

DSPE-PEG-Amine, MW 3400 (ammonium), is a phosphoethanolamine involved in the synthesis of liposomal delivery systems. The compound's amino group can be converted into an aromatic aldehyde to react with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. Liposomes are formed by creating bis-arylhydrazone (BAH) linkages with the target enzyme molecules, resulting in a liposome-BAH-BCA conjugate that can catalyze the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 5000 (ammonium), is a phosphatidylethanolamine that plays a role in the synthesis of liposomes for delivery systems. The amine group in DSPE-PEG-Amine, MW 5000 (ammonium) can be transformed into an aromatic aldehyde, which reacts with acetone-protected aromatic hydrazine on the surface of bovine carbonic anhydrase (BCA) molecules. The liposomes form bisaryl hydrazone (BAH) conjugates with the target enzyme molecules, resulting in liposome-BAH-BCA conjugates that can catalyze the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 10000 (ammonium) is a phosphoethanolamine involved in the synthesis of lipid-based delivery systems. The amine group on DSPE-PEG-Amine, MW 10000 (ammonium) can react with aromatic aldehydes on the surface of bovine carbonic anhydrase (BCA) molecules, forming bisarylhydrazones (BAH) with the target enzyme. This interaction results in a liposome-BAH-BCA conjugate capable of catalyzing the hydration of carbon dioxide into bicarbonate.

DSPE-PEG-Amine, MW 1000 ammonium is an amphiphilic polymer frequently employed in the preparation of liposomes and nanoparticles. Its amine group enables diverse functionalities including drug targeting, surface modification, and bioconjugation.

DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3DSPE-PEG(2000)-amine has also been used in the synthesis of fluorescein isothiocyanate-loaded mesoporous silica nanoparticles for imaging applications.4It can be conjugated to a variety of functional molecules for improved cellular targeting and uptake of DSPE-PEG(2000)-amine-containing nanoparticles.4,5 1.Sloat, B.R., Sandoval, M.A., Li, D., et al.In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticlesInt. J. Pharm.409(1-2)278-288(2011) 2.Abd-Rabou, A.A., Bharali, D.J., and Mousa, S.A.Taribavirin and 5-fluorouracil-loaded pegylated-lipid nanoparticle synthesis, p38 docking, and antiproliferative effects on MCF-7 breast cancerPharm. Res.35(4)76(2018) 3.Affram, K., Udofot, O., Singh, M., et al.Smart thermosensitive liposomes for effective solid tumor therapy and in vivo imagingPLoS One12(9):e0815116(2017) 4.Wang, L.-S., Wu, L.-C., Lu, S.-Y., et al.Biofunctionalized phospholipid-capped mesoporous silica nanoshuttles for targeted drug delivery: Improved water suspensibility and decreased nonspecific protein bindingACS Nano4(8)4371-4379(2010) 5.Wen, X., Wang, K., Zhao, Z., et al.Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticlesPLoS One9(9):e106652(2014)

DSPE-PEG(2000)-Amine is a useful organic compound for research related to life sciences and the catalog number is T64566.

DSPE-PEG(2000)-amine is a polyethylene glycol derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine, utilized in synthesizing solid lipid and thermosensitive liposome nanoparticles for cancer drug delivery.

DSPE-PEG-NHS, with a molecular weight of 1,000, is an amine-reactive phospholipid. The reaction between the NHS ester and an amine results in a stable amide bond. This polymer is amphiphilic, enabling it to form micelles or lipid bilayers in aqueous solutions.

DSPE-PEG4-NHS ester is a PEG-lipid derivative that can be used to form micelles for drug delivery nanoparticles. The NHS ester readily reacts with amino acids or other amine-containing molecules.