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By Target- Antibody-Drug Conjugates (ADCs)
- TROP2(1)
- Topoisomerase(1)
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By Target By ResearchField- Cancer(1)
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Results for "
ds 1062
" in TargetMol Product Catalog.- Inhibitors & Agonists1
- Inhibitory Antibodies1
- ADC/ADC Related1
- Datopotamab deruxtecanS-1062a, DS-1062, DS1062, Dato-DXdT397302238831-60-0Datopotamab deruxtecan (DS-1062) is an antibody-drug conjugate (ADC) that targets tropomyosin 2 (TROP2) on the surface of trophoblast cells. Datopotamab deruxtecan exhibits antitumor activity by specifically binding to TROP2 and internalizing, releasing DXd to inhibit topoisomerase I (IC₅₀ = 0.31 μM), thereby inducing DNA damage and apoptosis. Datopotamab deruxtecan induces significant antibody-dependent cellular cytotoxicity in the presence of peripheral blood lymphocytes and inhibits tumor growth in xenograft models.
- $1,060
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