dotap

DOTAP mesylate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids.

Fluorescent DOTAP, a cationic lipid, aids research in the delivery of nucleic acids and proteins [1].

DOTAP methylsulfate is a cationic lipid reagent and a trimethylammonium cation derivative, with two octadecanoic fatty acid chains in its molecular structure, each containing one unsaturated alkene bond. DOTAP can self-assemble with negatively charged nucleic acids such as DNA via electrostatic interactions to form complexes, which enter cells through electrostatic adsorption and endocytosis. The hydrophobic domain of DOTAP promotes endosomal membrane fusion and facilitates nucleic acid release into the cytoplasm, thereby achieving efficient gene delivery. Currently, DOTAP methylsulfate is widely used in gene therapy, in vitro cell transfection, non-viral vector construction, and related research fields.

DOTA-PEG5-amine, a PEG-based linker for PROTACs, connects two essential ligands to facilitate the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DOTA-PEG5-azide is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DOTA-PEG5-C4-DBCO is a PEG-based linker employed in PROTAC and bioconjugation applications, utilizing strain-promoted azide–alkyne cycloaddition (SPAAC) chemistry. The design of DOTA-PEG5-C4-DBCO enables ligation of functional ligands, facilitating targeted protein degradation via the ubiquitin–proteasome system and supporting modular assembly of advanced chemical probes.

DOTA-PSMA-EB-01 (Compound LNC1003) is a specific inhibitor of PSMA with an IC50 of 10.77 nM. It enhances tumor uptake and retention of 177Lu. DOTA-PSMA-EB-01 is applicable in the synthesis or research of radiolabeled conjugates (RDC).

DOTA-TMVP1446 is a peptide targeting VEGFR-3. When labeled with 68Ga, DOTA-TMVP1446 accurately detects lymph node metastasis, including micrometastases, in the B16-F10 tumor mouse model. It serves as a radioactive tracer for imaging metastatic sentinel lymph nodes (m-SLN) in cancer.

DOTA-Pep-1L TFA is a peptide resulting from the conjugation of DOTA with Pep-1L, where Pep-1L specifically targets the IL13RA2 receptor. DOTA-Pep-1L TFA is utilized in PET imaging and research on tumor-targeted therapies.

DOTA-Pep-1L is a peptide formed by the conjugation of DOTA with Pep-1L, where Pep-1L is a peptide specifically targeting the IL13RA2 receptor. DOTA-Pep-1L is applicable in PET imaging and research focused on tumor-targeted therapy.