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By Target- Histone Methyltransferase
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Results for "
dot1l-in-1
" in TargetMol Product Catalog- Inhibitors & Agonists5
Dot1L-IN-1
T110812088518-50-5
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
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Dot1L-IN-1 TFA
T73637
Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, with a K i of 2 pM and an IC50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC50 = 3 nM) and suppresses HoxA9 promoter activity (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively [1].
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Dot1L-IN-8
T201118
Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.
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S-N6-Methyladenosylhomocysteine
T20416853228-06-1
S-N6-Methyladenosylhomocysteine (Chart 1-1) is a potent inhibitor of the histone methyltransferase DOT1L, with an IC50 of 0.29 μM. This compound plays a significant role in cancer research.
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dot1l-in-7
T629152580940-76-5
Dot1L-IN-7 (compound 25) is a selective and potent inhibitor of telomere silencing 1-like protein (DOT1L) with an IC50 of 1.0 μM. It selectively kills MLL-AF9 cells without affecting the growth of E2A-HLF cells.
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