diphyllin

Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.

Diphyllin O-glucoside is a useful organic compound for research related to life sciences and the catalog number is T125096.

Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.

EBOV-IN-9 (compound 2b) is a Diphyllin derivative that inhibits Ebola virus entry with an EC50 of 40 nM. It effectively combats EBOV-infected monocyte-derived macrophages, showing an EC50 of 107 nM.