dimethyldioctadecylammonium (bromide)

Dimethyldioctadecylammonium bromide is a synthetic double-chain cationic lipid composed of a positively charged quaternary ammonium headgroup and two long-chain hydrophobic alkyl groups. It is capable of self-assembling into liposomes and nanoparticle systems and is commonly used in gene delivery and vaccine adjuvant development, where it promotes cellular uptake by forming complexes with nucleic acids; It also has applications as a surfactant and emulsifier.

Dimethyldioctadecylammonium-d3 bromide (Dioctadecyldimethylammonium-d3 bromide) is the deuterium-labeled variant of Dimethyldioctadecylammonium bromide. This synthetic cationic lipid is widely applied in gene transfer and vaccine development, known as DODAB or DDAB. Comprising a positively-charged ammonium head and two lengthy hydrophobic tails, it is adept at forming liposomes and various lipid-based nanoparticles for efficient genetic material delivery into cells. Beyond biotechnology, DDAB finds use as a surfactant, emulsifier, and fabric softener. However, its potential toxicity and irritant properties necessitate careful handling.