dichotomin

Dichotomin is a natural product of Paris, Liliaceae. The catalog number is TMA2055 and the CAS number is 53093-47-3. Dichotomin can be used as a reference standard.

Glucodichotomine B (Compound 13), a natural product extracted from the roots of the Chinese medicinal plant Stellaria dichotoma L. var. lanceolata, exhibits antitumor activity [1].

Dichotomine H, a β-carboline alkaloid derived from Stellaria dichotoma L., exhibits significant antiallergic activity [1].

Dichotomine A ((S)-(-)-Dichotomine A) is a β-carboline alkaloid found in the roots of Stellaria dichotoma.

Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline alkaloid with anti-allergic properties. It inhibits the release of β-hexosaminidase from RBL-2H3 cells with an IC50 of 62 μM. Additionally, it suppresses antigen IgE-mediated release of TNF-α and IL-4 in RBL-2H3 cells, with IC50 values of 19 μM and 15 μM, respectively. This compound is applicable in the research of type I hypersensitivity reactions.

Dichotomine E is a β-carboline alkaloid isolated from the roots of Stellaria dichotoma var. lanceolata. It possesses anti-inflammatory properties and can inhibit the production of NO in LPS-treated RAW264.7 cells.

Dichotomine D is a β-carboline alkaloid identified in the roots of Stellaria dichotoma. It functions as an anti-allergenic agent and shows potential for research in type I hypersensitivity reactions.

Dichotomine B is a natural alkaloid capable of modulating the TLR4/MyD88-mTOR signalling pathway, thereby attenuating neuroinflammatory responses in LPS/ATP-induced BV2 microglia.