depolarization — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0946	Mepivacaine hydrochloride	Mepivacaine HCl	Sodium Channel
	Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.		Sodium Channel
T2525	Alosetron hydrochloride	Lotronex,GR 68755C,GR 68755,GR 68755X	5-HT Receptor
	Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,...		5-HT Receptor
T27794	λ-Cyhalothrin	lambda-Cyhalothrin,Karate,Icon	Sodium Channel , Parasite
	λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group. It is employed across various applications for controlling a wide array of pes...		Sodium Channel , Parasite
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T0508	γ-Aminobutyric acid	Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid	GABA Receptor , Endogenous Metabolite
	γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system.		GABA Receptor , Endogenous Metabolite
T4S1876	3-Deoxyaconitine		Sodium Channel
	3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele...		Sodium Channel
T64394	GW 833972A		Cannabinoid Receptor
	GW 833972A is a selective CB2 receptor agonist.GW 833972A has an inhibitory effect on induced neural depolarization and on citric acid-induced cough in an animal model.		Cannabinoid Receptor
T13701	Genistein 8-c-glucoside	G8CG	Mitochondrial Metabolism
	Genistein 8-c-glucoside (G8CG) induces mitochondrial membrane depolarization and induces apoptosis. Genistein 8-c-glucoside (G8CG) is a natural glucoside isolated from flowers of Lupinus luteus L.		Mitochondrial Metabolism
T30249	AZD 7009	AZD-7009,AZD7009	Sodium Channel
	AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, an...		Sodium Channel
T7502L	PF 05089771	PF-05089771,PF05089771	Sodium Channel
	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.		Sodium Channel
T10706	CCI-006		Mitochondrial Metabolism
	CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfold...		Mitochondrial Metabolism
T0030	Bupivacaine hydrochloride	Vivacaine,Bupivacaine HCl	Sodium Channel
	Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...		Sodium Channel
T7995	α-Angelica lactone	Alpha-Angelica Lactone	Others , GST
	α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.		Others , GST
T0018	Procainamide hydrochloride	Procapan,Procainamide HCl,Pronestyl,Procanbid	DNA Methyltransferase , Sodium Channel , AChR , Autophagy
	Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to...		DNA Methyltransferase , Sodium Channel , AChR , Autophagy
T2535	Ivabradine hydrochloride	S 16257-2,Ivabradine HCl	Adrenergic Receptor
	Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat...		Adrenergic Receptor
T1320	Disopyramide	Triombrin,Hypaque sodium,amidotrizoate sodium	Potassium Channel , Sodium Channel , AChR
	Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...		Potassium Channel , Sodium Channel , AChR
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T61215	Alinidine hydrobromide
	Alinidine hydrobromide, a specific bradycardic agent, diminishes the slope of the diastolic depolarization in sinoatrial tissue and Purkinje fibers [1].
T68904	GW-833972A free base
	GW833972 is a CB2 Agonist. GW 833972A inhibited capsaicin-induced depolarization of the human and guinea-pig and prostaglandin E(2) (PGE(2)) and hypertonic saline-induced depolarization of the guinea-pig isolated vagus n...
T28562	Ro 18-3981	Ro-18-3981,Ro 183981
	Ro 18-3981 is an inhibition of myocardial Ca2+ channels. The KD value of Ro 18-3981 (1.0 nM) was similar to the IC50 value for blockade of ICa at a Vh of -20 mV (2.3 nM), i.e. at a level of near-maximal depolarization.