deoxycytidine triphosphate

Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

Deoxycytidine triphosphate-15N3 (dCTP-15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3) dilithium is a variant of deoxycytidine triphosphate labeled with 15N. dCTP is a nucleotide triphosphate utilized in DNA synthesis and is applicable in research areas such as real-time PCR, cDNA synthesis, and DNA sequencing.

Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.

Deoxycytidine triphosphate disodium is a biochemically defined nucleotide reagent that can be utilized as a biological material or organic compound in life science research. Deoxycytidine triphosphate supports applications in DNA synthesis, enzymatic assays, molecular biology workflows, and experimental systems requiring high-purity deoxynucleotide triphosphates for controlled biochemical reactions.

2'-Deoxycytidine is one of the major nucleosides of DNA consisting of cytosine and deoxyribose and inhibits the biological effects of bromodeoxyuridine (Brdu). The nucleoside consists only of a pentose sugar attached to a purine or pyrimidine base and has no phosphate group. When N1 is attached to C1 of deoxyribose, deoxyribosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), and deoxycytidine triphosphate (dCTP). cTP is the source of cytosine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of deoxycytidine in DNA (deoxyribonucleic acid). Itaconic acid is a polymer.

Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.

Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.

Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II and strongly competes with UTP incorporation into RNA, with a Ki value of 2.0 μM[1].

Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug.

Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S), an isomer of the sulfur-containing nucleotide derivative dCTP-α-S, functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibition constant (Ki) of 6.3 µM.

Cyclopentenylcytosine (CPC), a nucleoside analog, effectively inhibits CTP synthetase, leading to reduced levels of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells. Furthermore, it enhances the phosphorylation of 1-β-D-arabinorubosylmannosylcytidine (araC) and increases its DNA intercalation activity. In the human T lymphocyte line MOLT-3, cyclopentenylcytosine triggers apoptosis and necrosis in a dose (50-300 nM) and time (8-16 h) dependent manner. When used in conjunction with araC, cyclopentenylcytosine augments the induction of both apoptosis and necrosis, amplifying its cytotoxic effects on T lymphoblasts.

2'-Deoxycytidine (Standard) is the standard substance of 2'-Deoxycytidine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 2'-Deoxycytidine is one of the major nucleosides of DNA consisting of cytosine and deoxyribose and inhibits the biological effects of bromodeoxyuridine (Brdu). The nucleoside consists only of a pentose sugar attached to a purine or pyrimidine base and has no phosphate group. When N1 is attached to C1 of deoxyribose, deoxyribosides and nucleotides are formed from cytosine and deoxyribose; deoxycytidine monophosphate (dCMP), deoxycytidine diphosphate (dCDP), and deoxycytidine triphosphate (dCTP). cTP is the source of cytosine in RNA (ribonucleic acid) and deoxycytidine triphosphate (dCTP) is the source of deoxycytidine in DNA (deoxyribonucleic acid). Itaconic acid is a polymer.

5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that serves as a substrate for incorporating a fluorine modification into specific DNA sequences through primer extension catalyzed by Pwo polymerase (PEX).

Cyanine 3-dCTP is a nucleotide labeled with Cy3, used for DNA synthesis.

5-Iodo-dCTP serves as an excellent substrate for DNA polymerase and is utilized in DNA synthesis.

3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate (3'-O-Ac-dCTP) tetrasodium is a nucleotide triphosphate derivative that could be useful in DNA synthesis and nucleoside drug design. It can serve as an inhibitor of chain elongation reactions, functioning as either a terminator or a biochemical probe.