demethyleneberberine

Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor α, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator-1α pathway-associated fatty acid oxidation in chronic ethanol-fed mice.

Demethyleneberberine chloride is a metabolite of berberine and belongs to the class of isoquinoline alkaloid derivatives. Demethyleneberberine chloride is a naturally occurring antioxidant with mitochondrial targeting properties that alleviates colitis in mice and suppresses inflammation by inhibiting the NF-κB pathway and modulating Th cell balance. Demethyleneberberine chloride exerts metabolic regulatory effects by activating lipid metabolism and related signaling pathways (AMPK) and can be used in research on non-alcoholic fatty liver disease (NAFLD).