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Results for "
debio-0123
" in TargetMol Product Catalog- Inhibitors & Agonists1
Debio-0123
WEE1-IN-5
T98642243882-74-6
Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. Debio-0123 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].
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