dbco-peg-10-dbco

DBCO-PEG10-DBCO is a PEG-based linker used in PROTACs, joining two essential ligands needed to form PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

LG-PEG10-click-DBCO-Oleic is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) serves as a 10-unit PEG ADC linker in the fabrication of antibody-drug conjugates (ADCs) [1]. This compound also functions as a click chemistry reagent, featuring a TCO group capable of participating in an inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-containing molecules.

Biotin-PEG10-azide (Biotin-PEG10-N3) is a PEG derivative that integrates biotin, 10 PEG units, and an azide group. Biotin can form a stable, non-covalent bond with streptavidin. The azide group allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups and enables strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN group-containing molecules.