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By Target- Apoptosis
- Autophagy(1)
- JAK(1)
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Results for "
cyt 11387
" in TargetMol Product Catalog- Inhibitors & Agonists2
Momelotinib
Cited
LM-1149, CYT387, CYT11387
T18491056634-68-4
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1 2) with IC50 of 11 nM 18 nM. JAK1 2 inhibitor CYT387 competes with JAK1 2 for ATP binding, which may result in inhibition of JAK1 2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1 2-expressing tumor cells.
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