cycloheximide

Cycloheximide (Naramycin A) is a natural product . Cycloheximide‘s IC50 values for protein synthesis and RNA synthesis in vivo are 532.5 nM and 2880 nM, respectively. Cycloheximide inhibits ferroptosis and autophagy and is an antifungal antibiotic.

Acetoxycycloheximide induces cell surface TNF receptor 1. It also rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase.

Actiphenol is a glutarimide antibiotic that exhibits both antifungal and antitumor activity, demonstrating higher potency against pathogens such as coxsackievirus B3, influenza virus A, and herpes simplex virus type 2 than synthetic glutarimide derivatives, and Actiphenol production, along with cycloheximide biosynthesis, is controlled by a single gene cluster encoding an acyltransferase-less type I polyketide synthase in Streptomyces species, highlighting its importance in microbial natural product research.

Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.