ct 99021

CHIR-99021 (CT99021) is an activator of the Wnt β-catenin signaling pathway and a GSK-3α β inhibitor (IC50=10 6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in mouse and human embryonic stem cells.

Laduviglusib [CHIR 99021; CHIR99021; CHIR-99021; CT99021; CT 99021; CT-99021] is a potent, selective small-molecule inhibitor of glycogen synthase kinase 3 (GSK-3) with the formula C22H18ClN5O. It is used extensively in biomedical research to explore the role of GSK-3 in various cellular processes and diseases.

Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-3β with a Ki of 9.8 nM. Laduviglusib trihydrochloride is an activator of Wnt β-catenin signaling. Laduviglusib trihydrochloride induces autophagy.