cp 94253

CP94253 hydrochloride (CP 94253 hydrochloride) is a potent, selective and centrally active agonist of 5-HT1B receptor with Ki of 2 nM. The Kis are 89, 49, 860, and 1600 nM for 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, respectively.

CP94253 is an orally active selective agonist of the serotonin receptor 1B (5-HT1B), exhibiting agonistic activity by competitively binding to 5-HT1 receptors with iodocyanopindolol (ICP). It binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors with Ki values of 2, 89, 49, 860, and 1600 nM, respectively. In rat models, CP94253 induces satiety, anorexia, weight loss, and hyperactivity.