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(2)
By Target- Autophagy
- HSP(2)
- Wnt/beta-catenin(1)
- c-Myc(1)
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By Target By ResearchField- Cancer(1)
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Results for "
cnf-2024
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- BIIB021CNF2024, BIIB-021, BIIB 021T2286848695-25-0BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).
- $39
SizeQTY - BIIB021 mesylateCNF2024 mesylateT2132861225041-97-3BIIB021 (CNF2024) mesylate is the mesylate salt form of BIIB021. BIIB021 is an orally active Hsp90 inhibitor. It suppresses the proliferation of drug-resistant chronic myeloid leukemia (CML) cells, with IC50 values for K562, K562/G, 32Dp210, and 32Dp210-T315I cells recorded at 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 induces the degradation of BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. Furthermore, BIIB021 can induce autophagy in CML cells and is applicable for CML research.
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