cl-/hco3- exchanger

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

PAT1inh-B01 hydrochloride is a selective SLC26A6 inhibitor. It inhibits the anion exchange mediated by PAT1 (Cl-/HCO3- exchanger) with an IC50 of 350 nM. This compound blocks fluid absorption in the small intestine and can be used for research into diseases related to insufficient intestinal secretion.

PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange. It also obstructs fluid absorption in the small intestine and is utilized in the study of small intestinal hyposecretory disorders [1].