chloral

2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). It activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery [1]. [1]. Nikhil K Parelkar, et al. 2,2,2-trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery. J Pharmacol Exp Ther. 2010 Mar;332(3):803-10.

Penthrichloral exhibits sedative and hypnotic effects similar to chloral hydrate, but with a more pleasant taste and reduced gastric irritation. Additionally, Penthrichloral is also employed as an adhesive for polyester fibers.

Chloralose is an avicide and a rodenticide effective for controlling mice at temperatures below 15 °C. In addition. Chloralose is commonly used in neuroscience research and veterinary practice as an anesthetic and sedative. When used alone or together with agents such as urethane, chloralose provides long-lasting yet relatively light anesthesia.

Chloramine-T (Chloralone) is a N-chlorinated, and N-deprotonated sulfonamide, used as a biocide and a mild disinfectant.

Thalicminine is an alkaloid identified in Thalictrum species. It can induce respiratory stimulation and transient hypotensive effects in dogs. Additionally, Thalicminine prolongs the hypnotic action of chloral hydrate in mice.