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By Target- Apoptosis
- CDK(1)
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cgp 74514 dihydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists2
CGP 74514 dihydrochloride
T36349
Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002.
Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID:12702569 |Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID:10896313
- $713
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CGP-74514 dihydrochloride
T212234
CGP-74514 dihydrochloride is a highly selective inhibitor of cyclin-dependent kinase 1 (CDK1) with an IC50 of 25 nM. It effectively suppresses the activity of the CDK1/cyclin B complex, halting the cell cycle at the G2/M phase and inducing apoptosis in tumor cells. This compound shows potential for bladder cancer research.
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