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Results for "
cgp 52421
" in TargetMol Product Catalog- Inhibitors & Agonists3
(R)-3-Hydroxy Midostaurin
(R)-CGP52421
T12610155848-20-7
(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
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3-Hydroxy Midostaurin
CGP52421
T12610L179237-49-1
3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of approximately 132 nM in culture medium and 9.8 μM in plasma. Although less selective, it shows greater cytotoxicity compared to PKC412[1].
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(S)-3-Hydroxy Midostaurin
(S)-CGP52421
T12791945260-14-0
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
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