cefditoren pivoxil hcl

Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis.

Cefditoren Pivoxil is an orally active antibiotic with broad-spectrum antibacterial properties, and Cefditoren demonstrates potent inhibition against both Gram-negative and Gram-positive bacterial pathogens. Cefditoren exhibits a MIC50 of 0.25–0.5 mg/L against Streptococcus pneumoniae, Cefditoren is widely used for treating respiratory tract infections and skin infections. Cefditoren remains valuable in antimicrobial therapy owing to its favorable pharmacokinetic characteristics and reliable therapeutic efficacy.

Cefditoren sodium is a cephalosporin antibiotic potentially for the treatment of bacterial infection. The expression levels of Mrp2, Bcrp, Oat2 mRNA were markedly increased, while P-gp and Oct1 mRNA were decreased. In concordance with RT-PCR results, Mrp2