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(3)
By Target- CDK
- GSK-3(1)
- PKC(1)
- Others(1)
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By Target By ResearchField- Cancer(2)
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Results for "
cdk8-in-12
" in TargetMol Product Catalog.- Inhibitors & Agonists3
- CDK8-IN-12T720482613307-67-6In houseCDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
- $44
SizeQTY - CDK8-IN-14T860312924193-12-2CDK8-IN-14 (compound 12) effectively inhibits CDK8, demonstrating an IC50 of 39.2 nM, and exhibits potent anti-AML cell proliferation effects, with a GC50 value of 0.02±0.01μM in MOLM-13 cells and 0.03±0.01μM in MV4-11 cells [1].
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