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Results for "
ccr2 antagonist 3
" in TargetMol Product Catalog- Inhibitors & Agonists2
CCR2 antagonist 3
AZD-2927, AZD2927
T107121380100-86-6
CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.
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Emestrin
T3577297816-62-1
Emestrin, a mycotoxin originally isolated from *E. striata*, exhibits antimicrobial, immunomodulatory, and cytotoxic activities. It is effective against fungi *C. albicans* and *C. neoformans*, and bacteria *E. coli*, *S. aureus*, and methicillin-resistant *S. aureus* (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg ml, respectively). Emestrin acts as a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes). At 0.1 μg ml, it induces apoptosis in HL-60 cells and causes necrosis in heart, thymus, and liver tissues in mice at doses of 18-30 mg kg.
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