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Results for "
cas#1064195-48-7
" in TargetMol Product Catalog- Inhibitors & Agonists1
MF-592
T715101064195-48-7
MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg kg day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further development.
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