canonical — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2298	ML204		TRP/TRPV Channel
	ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.		TRP/TRPV Channel
T7399	LF3		Wnt/beta-catenin
	LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)		Wnt/beta-catenin
T15633	JW74		Wnt/beta-catenin
	JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).		Wnt/beta-catenin
T4662	SJ000291942		TGF-beta/Smad
	SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.		TGF-beta/Smad
T8820	BML-284 hydrochloride	BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin
	BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.		Wnt/beta-catenin
T22884	JW 67		Wnt/beta-catenin
	JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.		Wnt/beta-catenin
T9263	Cim0216	N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide	TRP/TRPV Channel
	CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.		TRP/TRPV Channel
T16687	Pyr3		TRP/TRPV Channel
	Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).		TRP/TRPV Channel
T8404	Kasugamycin hydrochloride hydrate	Ksg (hydrochloride hydrate)	Antibacterial , Antibiotic
	Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competitio...		Antibacterial , Antibiotic
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide	(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14	Wnt/beta-catenin
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...		Wnt/beta-catenin
T12797	RU-SKI 43	RUSKI 43	Hedgehog/Smoothened , Acyltransferase
	RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM.RU-SKI 43 has anticancer activity and is a potential compound for the treatment of lung adenocarcinomas.RU-SKI 43 reduc...		Hedgehog/Smoothened , Acyltransferase
T3701	MCC950	CP-456773	NOD
	CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and...		NOD
T15541	Hyperforin dicyclohexylammonium salt	Hyperforin DCHA	Others
	Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels.		Others
T34271	RBPI-3
	RBPI-3 is a canonical poly(ADP-ribose) glycohydrolase.
T13213	TRPC6-IN-1		Others
	TRPC6-IN-1 is an inhibitor of the Transient Receptor Potential Canonical 6 Channel (TRPC6) (EC50: 4.66 μM).		Others
T72008	E09241
	E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through c...
T60357	NF-κB-IN-2	JEUD-38
	NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.
T75550	Hyp9
	Hyp9, a specific agonist for the transient receptor potential canonical 6 (TRPC6) channel, is utilized in spinal cord injury (SCI) research [1].
T69842	DB2313 HCl
	DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets.
T71147	PBS-1086
	PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and sup...