calcium channel-modulator-1

Calcium channel-modulator-1, a calcium channel-modulator (IC50: 0.8 μM), specializes in blocking aortic constriction.

Maxi-K modulator 1 (Example 1) is a modulating agent for the large conductance calcium-activated potassium (Maxi-K) channels. It serves as a potent stimulator of Maxi-K channel activity and is applicable in research on Fragile X syndrome.

TMEM16A modulator-1 (compound 36) is a positive modulator of calcium-activated chloride channel (CaCC) TMEM16A. It is useful for research associated with TMEM16A-related diseases, particularly in studying respiratory system diseases and conditions.

Anti-Orai1 Antibody is a humanized monoclonal antibody targeting Calcium Release-Activated Calcium Modulator 1 (Orai1/CRACM1). Orai1 forms the pore subunit of the Calcium Release-Activated Calcium (CRAC) channel on the plasma membrane, mediating Store-Operated Calcium Entry (SOCE). In T lymphocytes, antigen receptor stimulation depletes endoplasmic reticulum calcium stores, triggering STIM1 to activate Orai1 and induce sustained calcium influx, a critical step for NFAT activation and cytokine (e.g., IL-2) production. This antibody specifically binds to the extracellular loops of Orai1, blocking the channel pore or disrupting STIM1-Orai1 coupling, thereby inhibiting SOCE and downstream immune responses. It is widely used in research on autoimmune diseases, inflammation, and calcium signaling-dependent tumors.