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By Target- Calcium Channel
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Results for "
calcium channel-modulator-1
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Inhibitory Antibodies1
Calcium channel-modulator-1
T10101136941-70-3In house
Calcium channel-modulator-1, a calcium channel-modulator (IC50: 0.8 μM), specializes in blocking aortic constriction.
- $115
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QTY
Anti-Orai1 Antibody
T9901A-1441
Anti-Orai1 Antibody is a humanized monoclonal antibody targeting Calcium Release-Activated Calcium Modulator 1 (Orai1/CRACM1). Orai1 forms the pore subunit of the Calcium Release-Activated Calcium (CRAC) channel on the plasma membrane, mediating Store-Operated Calcium Entry (SOCE). In T lymphocytes, antigen receptor stimulation depletes endoplasmic reticulum calcium stores, triggering STIM1 to activate Orai1 and induce sustained calcium influx, a critical step for NFAT activation and cytokine (e.g., IL-2) production. This antibody specifically binds to the extracellular loops of Orai1, blocking the channel pore or disrupting STIM1-Orai1 coupling, thereby inhibiting SOCE and downstream immune responses. It is widely used in research on autoimmune diseases, inflammation, and calcium signaling-dependent tumors.
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