brl-2288

Ticarcillin sodium (Aerugipen hydrate) is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.

Ticarcillin disodium (Ticarpen) is the disodium salt form of ticarcillin, a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Similar to carbenicillin in action, ticarcillin inactivates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.

Ticarcillin monosodium, a semisynthetic carboxypenicillin antibacterial agent, exhibits broad-spectrum activity against gram-positive cocci such as streptococci and staphylococci. It is also effective against most gram-negative organisms, notably Pseudomonas aeruginosa. The compound is utilized in the treatment of various infections, including those of the lower respiratory tract, skin and skin structures, urinary tract, and intraabdominal infections, according to research [1] [2] [3].

Ticarcillin disodium is an antibiotic derived from penicillin. It is similar to Carbenicillin in action.