bis-peg-9-acid

Bis-PEG9-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG-bis-amine (MW 8000) is utilized to synthesize folate-conjugated polymeric micelles, encapsulating the insoluble anticancer agent 9-nitrocamptothecin. These folic acid-conjugated polymer micelles serve as efficient carriers that not only evade macrophages but also facilitate the folate receptor (FR)-mediated endocytosis in tumor cells, enhancing drug delivery.

PEG-bis-amine (MW 1000) is used to synthesize folate-conjugated polymer micelles that encapsulate the anticancer agent 9-nitrocamptothecin. These folic acid-conjugated polymer micelles effectively deliver insoluble anticancer drugs, evading macrophages and facilitating endocytosis by tumor cells through folate receptors (FR).