bis-mal-peg-5

Bis-Mal-PEG5 is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Mal-PEG2-bis-PEG3-BCN, a cleavable five-unit PEG linker, is utilized in the synthesis of antibody-drug conjugates (ADCs) [1]. It functions as a click chemistry reagent featuring a BCN group capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.