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By Target- ADC Linker
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Results for "
bi-3663
" in TargetMol Product Catalog- Inhibitors & Agonists3
- PROTAC Products3
N3-PEG3-CH2CH2COOH
T162581056024-94-2
N3-PEG3-CH2CH2COOH, a PEG-based PROTAC linker, is utilized in the synthesis of BI-3663, BI-4216, and BI-0319. Additionally, Azido-PEG3-acid, a non-cleavable 3-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).
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Tos-PEG4-t-butyl ester
Tos-PEG4-Boc
T17133217817-01-1
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition, crucial in synthesizing various PROTACs, including BI-3663, a selective PTK2 FAK PROTAC. Using cereblon ligands, it targets E3 ligases to degrade PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
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