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Results for "
basimglurant
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- BasimglurantRG7090, CTEP DerivativeT12717802906-73-6Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).
- $68
SizeQTY - Basimglurant sulfateRO4917523 sulfate, RG7090 sulfateT2190431034442-21-1Basimglurant (RG7090; RO4917523) sulfate is a selective, orally bioavailable negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5) that can cross the blood-brain barrier. It exhibits a Ki of 1.4 nM for [³H]-ABP688 and 35.6 nM for [³H]-MPEP. Basimglurant sulfate inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, modulates nucleus accumbens dopamine levels, and exerts anxiolytic, antidepressant-like, analgesic, and wakefulness-promoting effects, while altering δ-wave power during non-rapid eye movement sleep. It is applicable in research related to depression, fragile X syndrome, and anxiety disorders.
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