azido-peg1-boc

Azido-PEG1-Boc, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker employed in PROTAC synthesis[1].

Boc-PEG1-PPG2-C2-azido is a PROTAC linker of the PEG class, utilized in PROTAC molecule synthesis. This compound acts as a click chemistry reagent containing an azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.