azido peg8 azide

Azido-PEG8-azide is a PEG-based linker used in PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG8-THP is a PROTAC linker classified under the PEG family, utilized in the synthesis of PROTAC molecules. This compound serves as a click chemistry reagent and contains an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.