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Results for "
azd 0780
" in TargetMol Product Catalog.- Inhibitors & Agonists1
- AZD0780PCSK9-IN-12, EX-A6975T643622455427-91-3AZD0780 (EX-A6975, PCSK9-IN-12) is an orally active PCSK9 inhibitor with high affinity for PCSK9 (Kd < 200 nM). It binds to a specific pocket in the C-terminal domain of PCSK9 without affecting the PCSK9–LDLR interaction. AZD0780 blocks the lysosomal trafficking of the PCSK9–LDLR complex and prevents PCSK9-induced LDLR degradation, making it useful for studies related to hypercholesterolemia.
- $66
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