atpase, na+/k+ transporting, b 1 polypeptide

ATP1B1 belongs to the family of Na+ K+and H+ K+-ATPases beta chain proteins, and to the subfamily of Na+ K+ -ATPases. ATP1B1 is a subunit of Na+ K+-ATPase. Na+ K+-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. Na+ K+-ATPase is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). ATP1B1 regulates, through assembly of alpha beta heterodimers, the number of sodium pumps transported to the plasma membrane. ATP1B1 is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with which catalyzes the hydrolysis of ATP coupled with the exchange of Na+and K+ions across the plasma membrane.