armepavine

Armepavine (R-Armepavine) exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBP pathways. It improves experimental autoimmune crescentic glomerulonephritis.

(+)-Armepavine is an active compound from Nelumbo nucifera that exhibits anti-inflammatory effects on human peripheral blood mononuclear cells, immunosuppressive effects on T lymphocytes, and protective activity in lupus nephritic mice, in part by inhibiting TNF-α-induced MAPK and NF-κB signaling pathways.

Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.

N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa

N-Methylarmepavine is a natural product that can be used as a reference standard. The CAS number of N-Methylarmepavine is 74046-21-2.