apdc

(2R,4R)-APDC, a selective group II metabotropic glutamate receptors (mGluRs) agonist, exhibits anticonvulsant and neuroprotective effects.

Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.

1-Benzyl-APDC acts as an agonist for mGluR6 in CHO cells, exhibiting an EC50 of 20 μM. Additionally, it functions as a weak antagonist for mGluR2, with an IC50 of 200 μM.

(2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is an agonist for group II metabotropic glutamate receptors (mGluR). It influences cell proliferation by inhibiting glutamate release, enhancing motor responses generated by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. This compound is applicable in research on epilepsy and other neurological disorders.