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Search Result

Search Results for " antidepressant-like "

Targets

MAO Monoamine Oxidase

49

Compounds

16

Natural Products

Cat No. Product Name Synonyms Targets
T18918 Azure B Azure B chloride MAO , Monoamine Oxidase
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
T39341 FCPR03 PDE
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...
T16421 P-MPPI hydrochloride 5-HT Receptor
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
T21995 XAP044 GluR
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T19916 TRIM 1-(2-Trifluoromethylphenyl)imidazole NOS
TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS.
T6714 URB-597 KDS-4103,FAAH Inhibitor II Mitophagy , FAAH , Autophagy
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T7601L Carbetocin acetate Carbetocin acetate(37025-55-1 free base) Oxytocin Receptor
Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
T7601 Carbetocin Oxytocin Receptor
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
T61518 TAK-653 iGluR
TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models.
T23349 SF 11 Others
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist with IC50 of 199 nM. Antidepressant-like activity
T22051 BU 224 hydrochloride Imidazoline Receptor
BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.
T34374 RO5203648 HCl RO5203648,RO-5203648,RO 5203648 Others
RO5203648 HCl is a partial agonist of trace amine-related receptor 1 (TAAR1) with antipsychotic and antidepressant-like activities. RO5203648 HCl can be used in studies about neuropsychiatric therapeutics.
T13164 Tipepidine hydrochloride Potassium Channel , Dopamine Receptor
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
T60201 CX717 GluR
CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD) [1] [2].
T8414 SNC 80 Snc-80,SNC80,NIH 10815 Opioid Receptor
SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 show...
T26152 RU 43044 RU-43044,RU-044,RU044,RU43044
RU 43044 is a selective glucocorticoid receptor antagonist that has exhibited an antidepressant-like effect.
T16408 Osanetant SR142801 Others
Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia.
T70880 TAK-137
TAK-137 is a novel AMPA receptor potentiator with little agonistic effect, producing antidepressant-like effect without causing psychotomimetic effects.
T40778 Tyrosylleucine TFA Tyr-Leu TFA
Tyrosylleucine (Tyr-Leu, YL) TFA is a dipeptide compound with potent antidepressant-like activity. This orally active compound demonstrates effective modulation of depressive symptoms.
T37622 F13714 fumarate F13714 fumarate
F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].
T28034 MGS-0039 BCI 632,BCI-632,MGS0039,BCI632
MGS-0039 is a group II metabotropic glutamate receptor (mgluR2/3) antagonist. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor...
T70292 DDPM-2571 HCl
DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and...
T11911 LY3020371 hydrochloride GluR
LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks ...
T39120 Fluoroethylnormemantine
Fluoroethylnormemantine, a derivative of Memantine, acts as an N-methyl-D-aspartate (NMDA) receptor antagonist. It can function as a positron emission tomography (PET) tracer, known as [18F]-fluoroethylnormemantine. This...
T22194 BW 373U86
BW373U86 (SNC86), a δ-opioid receptor agonist, demonstrates potent activity with an IC50 value of 1.49 nM and has shown to exhibit antidepressant-like effects [1].
T39119 Fluoroethylnormemantine hydrochloride
Fluoroethylnormemantine hydrochloride, a Memantine derivative, functions as an antagonist for the N-methyl-D-aspartate (NMDA) receptor. It can also serve as a positron emission tomography (PET) tracer, specifically as [1...
T61506 NBI-31772 hydrate
NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-...
T70487 Tofenacin (free base)
Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic...
T79229 ETAP Monoamine Oxidase
ETAP, a dual inhibitor of both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B), exhibits antidepressant-like effects and is utilized in the research of major depressive disorder [1].
TP1127 Nemifitide diTFA INN 00835 diTFA 5-HT Receptor
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.
T37823 M 084 hydrochloride
TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimizati...
T71537 Tofenacin hydrochloride
Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinerg...
T79325 5-HT6 agonist 1 5-HT Receptor
Compound 19, a 5-HT6 agonist with an affinity (K i : 5 nM), exhibits antidepressant-like effects and enhances cognitive function while also inhibiting platelet aggregation. It demonstrates high metabolic stability [1].
T73568 MTEP
MTEP, a potent, non-competitive, and highly selective antagonist of mGluR5, exhibits an IC50 value of 5 nM and a K_i value of 16 nM. Demonstrating antidepressant and anxiolytic-like effects, MTEP is utilized in Parkinson...
T74413 (S)-Osanetant
(S)-Osanetant, the S-enantiomer of Osanetant (SR142801), is a selective NK3 receptor antagonist known for its anxiolytic- and antidepressant-like effects. It is currently under investigation for potential use in treating...
T60501 Tipepidine
Tipepidine is a non-narcotic antitussive with an antidepressant-like effect. Tipepidine reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK) ) (IC 50 = 7.0 μM) and subsequently activates VTA do...
T61617 Hcyb1
Hcyb1 is a potent and specific inhibitor of phosphodiesterase 2 (PDE2). It exhibits a high degree of selectivity for inhibiting PDE2A with an IC50 value of 0.57 μM. In addition, Hcyb1 displays over 250-fold selectivity a...
T75895 UFP-101 TFA
UFP-101 TFA is a potent, selective, and competitive N/OFQ peptide (NOP) receptor antagonist, boasting a pK i value of 10.24 and demonstrating over 3000-fold selectivity against δ, μ, and κ opioid receptors. It exhibits a...
T35560 SAR502250
SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM. It exhibits antidepressant-like activity and is being researched for potential...
T26225 SRA880 malonate SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880
SRA880 is a non-peptide somatostatin sst(1) receptor antagonist which displays a significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d)= 6.0) or a wide range of neurotransmitter recep...
T62711 OPC-14523 hydrochloride
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity. OPC-14523 shows a high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 ...
T62064 PDE4B/7A-IN-2
This compound is a dual 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with additional inhibitory activity against PDE4B/PDE7A (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 ...
T28851 SRA880 free base SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880
SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding a...
T78868 TWIK-1/TREK-1-IN-1 Potassium Channel
Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as a...
T73631 (Rac)-SNC80
(Rac)-SNC80, a racemate of SNC80 (NIH 10815), is a potent, highly selective non-peptide δ-opioid receptor agonist, characterized by a K_i of 1.78 nM and an IC_50 of 2.73 nM. Demonstrating antinociceptive, antihyperalgesi...
T83676 Tianeptine Metabolite MC5 sodium
Tianeptine metabolite MC5, an active derivative of the atypical antidepressant tianeptine produced through β-oxidation, exhibits selective G protein activation in bioluminescence resonance energy transfer (BRET) assays. ...
T35814 Urocortin III (human) (trifluoroacetate salt)
Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin II...
T36521 Alaproclate (hydrochloride)
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =...

Compounds

Azure B
T18918
Synonym: Azure B chloride
Target: MAO, Monoamine Oxidase
FCPR03
T39341
Synonym:
Target: PDE
p-MPPI hydrochloride
T16421
Synonym:
Target: 5-HT Receptor
XAP044
T21995
Synonym:
Target: GluR
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
TRIM
T19916
Synonym: 1-(2-Trifluoromethylphenyl)imidazole
Target: NOS
URB-597
T6714
Synonym: KDS-4103,FAAH Inhibitor II
Target: Mitophagy, FAAH, Autophagy
Carbetocin acetate
T7601L
Synonym: Carbetocin acetate(37025-55-1 free base)
Target: Oxytocin Receptor
Carbetocin
T7601
Synonym:
Target: Oxytocin Receptor
TAK-653
T61518
Synonym:
Target: iGluR
SF 11
T23349
Synonym:
Target: Others
BU 224 hydrochloride
T22051
Synonym:
Target: Imidazoline Receptor
RO5203648 HCl
T34374
Synonym: RO5203648,RO-5203648,RO 5203648
Target: Others
Tipepidine hydrochloride
T13164
Synonym:
Target: Potassium Channel, Dopamine Receptor
CX717
T60201
Synonym:
Target: GluR
SNC 80
T8414
Synonym: Snc-80,SNC80,NIH 10815
Target: Opioid Receptor
RU 43044
T26152
Synonym: RU-43044,RU-044,RU044,RU43044
Target:
Osanetant
T16408
Synonym: SR142801
Target: Others
TAK-137
T70880
Synonym:
Target:
Tyrosylleucine TFA
T40778
Synonym: Tyr-Leu TFA
Target:
F13714 fumarate
T37622
Synonym: F13714 fumarate
Target:
MGS-0039
T28034
Synonym: BCI 632,BCI-632,MGS0039,BCI632
Target:
DDPM-2571 HCl
T70292
Synonym:
Target:
LY3020371 hydrochloride
T11911
Synonym:
Target: GluR
Fluoroethylnormemantine
T39120
Synonym:
Target:
BW 373U86
T22194
Synonym:
Target:
Fluoroethylnormemantine hydrochloride
T39119
Synonym:
Target:
NBI-31772 hydrate
T61506
Synonym:
Target:
Tofenacin (free base)
T70487
Synonym:
Target:
ETAP
T79229
Synonym:
Target: Monoamine Oxidase
Nemifitide diTFA
TP1127
Synonym: INN 00835 diTFA
Target: 5-HT Receptor
M 084 hydrochloride
T37823
Synonym:
Target:
Tofenacin hydrochloride
T71537
Synonym:
Target:
5-HT6 agonist 1
T79325
Synonym:
Target: 5-HT Receptor
MTEP
T73568
Synonym:
Target:
(S)-Osanetant
T74413
Synonym:
Target:
Tipepidine
T60501
Synonym:
Target:
Hcyb1
T61617
Synonym:
Target:
UFP-101 TFA
T75895
Synonym:
Target:
SAR502250
T35560
Synonym:
Target:
SRA880 malonate
T26225
Synonym: SRA880,NVPSRA880,NVP-SRA880,NVP-SRA-880,NVP-SRA 880,NVP SRA880
Target:
OPC-14523 hydrochloride
T62711
Synonym:
Target:
PDE4B/7A-IN-2
T62064
Synonym:
Target:
SRA880 free base
T28851
Synonym: SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880
Target:
TWIK-1/TREK-1-IN-1
T78868
Synonym:
Target: Potassium Channel
(Rac)-SNC80
T73631
Synonym:
Target:
Tianeptine Metabolite MC5 sodium
T83676
Synonym:
Target:
Urocortin III (human) (trifluoroacetate salt)
T35814
Synonym:
Target:
Alaproclate (hydrochloride)
T36521
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3886 Rosavin Rosavidin P450
Rosavin (Rosavidin) has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.
T3856 Tenuifoliside A ERK , Others
Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.
T5648 Purpurin 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin MAO , Antibacterial , Antibiotic , Antifungal
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.
T3933 Jatrorrhizine Yatrorizine,neprotin MAO , 5-HT Receptor , Antibacterial , AChE
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...
T4912 Jatrorrhizine chloride Yatrorhizine chloride,Neprotine chloride Others , 5-HT Receptor , OCT , Antibacterial , AChE
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...
T9112 (-)-Perillaldehyde AhR , ROS , Nrf2
(-)-Perillaldehyde shows antibacterial activity.
T3698 Alpha-Asarone α-Asarone,trans-Asarone P450 , GABA Receptor , HMG-CoA Reductase
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T5S2204 Sibiricose A6 Antioxidant
1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.
T5S2195 Sibiricose A5 Dehydrogenase
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.
T7448 4-Hydroxyisoleucine 4-​Hydroxy-​L-​isoleucine Others
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity.
T5S0331 Isoliquiritin Neoisoliquritin p53 , Antifungal
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk betwee...
TN1420 Bacopaside I Others
Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ...
T3386 Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside cell cycle arrest , Glucokinase , IGF-1R
Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...
T3S1553 Trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein COX , Endogenous Metabolite
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...
T6S0721 Orientin Lutexin,Luteolin-8-glucoside Others
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...
TN1415 Auraptenol 5-HT Receptor
Auraptenol possesses robust antidepressant-like efficacy in mice.

Natural Products

Rosavin
T3886
Synonym: Rosavidin
Target: P450
Tenuifoliside A
T3856
Synonym:
Target: ERK, Others
Purpurin
T5648
Synonym: 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin
Target: MAO, Antibacterial, Antibiotic, Antifungal
Jatrorrhizine
T3933
Synonym: Yatrorizine,neprotin
Target: MAO, 5-HT Receptor, Antibacterial, AChE
Jatrorrhizine chloride
T4912
Synonym: Yatrorhizine chloride,Neprotine chloride
Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE
(-)-Perillaldehyde
T9112
Synonym:
Target: AhR, ROS, Nrf2
alpha-Asarone
T3698
Synonym: α-Asarone,trans-Asarone
Target: P450, GABA Receptor, HMG-CoA Reductase
Sibiricose A6
T5S2204
Synonym:
Target: Antioxidant
Sibiricose A5
T5S2195
Synonym:
Target: Dehydrogenase
4-Hydroxyisoleucine
T7448
Synonym: 4-​Hydroxy-​L-​isoleucine
Target: Others
Isoliquiritin
T5S0331
Synonym: Neoisoliquritin
Target: p53, Antifungal
Bacopaside I
TN1420
Synonym:
Target: Others
Kaempferitrin
T3386
Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside
Target: cell cycle arrest, Glucokinase, IGF-1R
trans-Cinnamaldehyde
T3S1553
Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein
Target: COX, Endogenous Metabolite
Orientin
T6S0721
Synonym: Lutexin,Luteolin-8-glucoside
Target: Others
Auraptenol
TN1415
Synonym:
Target: 5-HT Receptor
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