anti-orthopoxvirus

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.

Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.

ITGB3-IN-1 is an orally active integrin β3 subunit (ITGB3) inhibitor with a Kd of 7.26 μM. This compound demonstrates potent anti-orthopoxvirus activity, exhibiting an EC50 of 1.82 μM against vaccinia virus (VACV). ITGB3-IN-1 also inhibits hERG with an IC50 of 1.13 μM and can be utilized in orthopoxvirus research.

HOE961 is the diacetate ester prodrug of S2242 with anti-orthopoxvirus activity. HOE961 is orally active in infection models. HOE961 is active against respiratory cowpox virus infections [1].