anti-hormonal

Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.

Nilutamide (RU23908), an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progestogen, or glucocorticoid receptors. Therefore, Nilutamide can block the action of androgens of testicular and adrenal origin that stimulate the growth of malignant and normal prostatic tissue. Prostate Y is mainly androgen-dependent and can be treat with chemical castration or surgical. So far, antiandrogen monotherapy has not consistently been certified to be equivalent to castration.

Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition and substantially decreases hormonal effects.

EP055 is a non-hormonal male contraceptive agent. It targets the EPPIN protein on the surface of sperm, thereby inhibiting the binding of anti-EPPIN antibodies to EPPIN, with an IC50 value of 1121 μM. By reducing the internal pH and Ca2+ levels of sperm, EP055 induces sperm aggregation and inhibits sperm motility (IC50 value of 199.5 μM). EP055 is applicable in the development of male contraceptives.