anion exchanger

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.

AEX Anion-exchange resin 1 is a strong anion exchange chromatographic medium with a monodisperse polystyrene/divinylbenzene (PS-DVB) matrix and a particle size of 50 μm, featuring an ion exchange group of –CH2N+(CH3)3. It is suitable for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

AEX Anion-exchange resin 2 is a commonly used material for AEX applications, serving as a strong anion exchange medium with a particle size of approximately 90μm. It is suitable for use in ion exchange chromatography.

AEX HQ Anion-exchange resin (POROS 50HQ) is a commonly used packing material in AEX. This HQ strong anion-exchange resin is capable of purifying target proteins.

Xipamide (Diurexan) is a sulfonamide-based diuretic with antihypertensive properties. Xipamide selectively inhibits anion exchanger.

H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger.

DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor.

PAT1inh-B01 hydrochloride is a selective SLC26A6 inhibitor. It inhibits the anion exchange mediated by PAT1 (Cl-/HCO3- exchanger) with an IC50 of 350 nM. This compound blocks fluid absorption in the small intestine and can be used for research into diseases related to insufficient intestinal secretion.

Beta-D-Glucopyranosyl nitromethane is a glycosyl derivative of nitromethane, functioning as a salt of a highly basic anion exchanger in the OH cycle.

PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange. It also obstructs fluid absorption in the small intestine and is utilized in the study of small intestinal hyposecretory disorders [1].