amino-peg12-acid

Amino-PEG12-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Amino-SS-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is commonly used in the synthesis of antibody-drug conjugates (ADCs)[1].

Acid-PEG12-NHS ester is a PEG derivative featuring an NHS ester, which can react with amino acids or other molecules containing amino groups.

t-Boc-N-amido-PEG12-acid is a PEG linker featuring a terminal carboxylic acid and a Boc-protected amino group. The hydrophilic PEG spacer enhances solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (such as EDC or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to yield a free amine.