als-8112

ALS-8112 (ALS 008112) is a selective and potent inhibitor of respiratory syncytial virus (RSV) polymerase with an IC50 value of 0.02 μM. ALS-8112 exhibits antiviral activity and inhibits the RNA polymerase activity of the RSV L-P protein complex through RNA chain termination. virus infections.

ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112. This compound acts as a potent, selective, and competitive inhibitor of respiratory syncytial virus (RSV) RNA polymerase, demonstrating selectivity over host or unrelated viral polymerases, such as the hepatitis C virus (HCV). It is efficiently recognized by the recombinant RSV polymerase complex, resulting in the termination of RNA synthesis. ALS-8112-TP is applicable in the research of RSV infections.